Abstract
Silicone oil (SO) is widely used as a long-term intravitreal tamponading agent for rhegmatogenous retinal detachment (RRD) repair. This study investigated the structural changes of the foveal microvasculature using optical coherence tomography angiography (OCTA) in patients with RRD treated with vitrectomy and SO tamponade. Thirty-eight patients with unilateral RRD who were treated with vitrectomy and SO tamponade and were followed up for ≥3 months after SO removal were included. En face OCTA images were obtained and foveal avascular zone (FAZ) area and vascular density (VD) were compared between study eyes and unaffected contralateral eyes. The FAZ area in deep capillary plexus (DCP) was larger (P < 0.001) and the VD in DCP was lower (P = 0.022) in the study eyes than in the fellow eyes. The duration of SO tamponade was significantly correlated with the enlargement of FAZ area (P = 0.034) and reduction of VD in DCP (P = 0.015). These changes could reflect vascular insufficiency in eyes with SO tamponade and may represent a potential explanation for the pathogenesis of retinal thinning and unexplained visual loss.
Highlights
Tamponade using spectral-domain optical coherence tomography (SD-OCT)[11,12,13], changes in foveal microvascular structures in response to silicone oil using optical coherence tomography angiography (OCTA) have not yet been investigated
Using OCTA, we provide evidence that silicone oil injection for the treatment of rhegmatogenous retinal detachment (RRD) could cause changes in the foveal microvascular structures, larger foveal avascular zone (FAZ) area and lower vascular density (VD) in the deep capillary plexus (DCP)
A multivariate regression analysis demonstrated that the duration of silicone oil tamponade is significantly correlated with enlargement of FAZ and reduction of VD in the DCP
Summary
Tamponade using spectral-domain optical coherence tomography (SD-OCT)[11,12,13], changes in foveal microvascular structures in response to silicone oil using OCTA have not yet been investigated. The aim of this study was to evaluate foveal microvascular structures of patients who underwent silicone oil injection for the treatment of RRD. We compared changes in retinal thickness and foveal microvasculature between the treated and the normal contralateral eyes 3 months after silicone oil removal. Factors related to changes in foveal microvasculature were evaluated
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
