Four vitamins combined with FE composite enzyme collutory in treatment of recurrent oral ulcer

Abstract

Objective To study the clinical efficacy of four vitamins combined with FE composite enzyme collutory in the treatment of recurrent oral ulcer. Methods From January, 2015 to May, 2016, 72 patients with recurrent oral ulcer treated at our hospital were selected as study objects and were randomly divided into group A (24 cases), group B (24 cases), and group C (24 cases). All the groups were given traditional treatment; in addition, group A were given four vitamins (vitamin E soft capsules + vitamin B2 + mecobalamin tablets + folic acid tablets), group B FE composite enzyme collutory, and group C four vitamins and FE composite enzyme collutory. The mean ulcer time, total ulcer number, ulcer pain index, total ulcer intermission in follow-up period, and clinical efficacy in the three groups were compared. Results After treatment, the mean ulcer time was shorter, the total ulcer intermission was longer, the total ulcer number was smaller, and the ulcer pain index was lower in group C than in group A and group B, with statistical differences (all P<0.05) . The total effective rate was 95.83% in group C, 58.33% in group A, and 66.67% in group B, with statistical differences (all P<0.05) . Conclusion Four vitamins combined with FE composite enzyme collutory has good clinical efficacy and none obvious adverse reactions in the treatment of recurrent oral ulcer, so it is a good choice for recurrent oral ulcer in clinic. Key words: Four vitamins; FE composite enzyme collutory; Recurrent oral ulcer; Clinical efficacy