Four new compounds from Zygophyllum fabago L.

Abstract

Phytochemical investigation of Zygophyllum fabago L. afforded seven compounds, including a new valencane type sesquiterpenoid (1), a new phenylpropanoid derivative (2) and two new quinovic acid derivatives (3 and 4), and 3-O-[β-d-glucopyranosyl]-quinovic acid (5). Their structures were elucidated by the extensive use of 1D (1H NMR and 13C NMR) and 2D (COSY, HSQC, HMBC and ROESY) NMR experiments, as well as IR and HREIMS spectral data. These new compounds were evaluated for their cytotoxic activity against five cancer cell lines (HL-60, SMMC-721, A-549, MCF-7, and SW-480). All new compounds exhibited no cytotoxic activities (>40μm).