Abstract
Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus.
Highlights
The search for new bioactive natural products is still the main way of discovering new drugs.Investigating the secondary metabolites of microorganisms isolated from specific ecological environments may increase the chance of finding compounds with novel skeletons and varied and unique bioactivities
In order to search for new bioactive natural products, a marine-derived fungal strain, ML226, authenticated as Penicillium sp., was isolated from the Taiwan Strait, China
We report the isolation and structural elucidation of compounds 1–10 and the cytotoxic and antimicrobial activity of 1–4
Summary
The search for new bioactive natural products is still the main way of discovering new drugs. Investigating the secondary metabolites of microorganisms isolated from specific ecological environments may increase the chance of finding compounds with novel skeletons and varied and unique bioactivities. In order to search for new bioactive natural products, a marine-derived fungal strain, ML226, authenticated as Penicillium sp., was isolated from the Taiwan Strait, China. Chemical investigation of the EtOAc extract of Penicillium sp. We report the isolation and structural elucidation of compounds 1–10 and the cytotoxic and antimicrobial activity of 1–4. They all showed weak cytotoxicity against HepG-2 cell line in the concentration of 10 μg/mL with inhibition rate from 6% to. Compounds 2 and 3 showed weak antimicrobial activity against Staphylococcus aureus
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