Abstract
Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns. This is the first systematic report on the mass spectrometric characteristics of prenylated indole derivatives.
Highlights
Natural products are important sources of drugs and drug leads [1,2]
As an essential part of marine microbes, marine-derived fungi have proven to be a major source of marine natural products due to their complex genetic background and chemodiversity [5,6]
Prenylated indole alkaloids were isolated from the secondary metabolites of Penicillium sp
Summary
Natural products are important sources of drugs and drug leads [1,2]. In recent years, numerous biologically active natural products have been isolated from microbes collected from different environments such as plants, animals, soils, and sediments [3]. The genus Penicillium has received great attention among all marine-derived fungi, which account for 22% of all natural products of marine fungal origin [7] Their various secondary metabolites usually have uncommon structures and potent bioactivities that might possess substantial pharmaceutical values [8]. 2017, 15, describes mass spectrometric characteristics of prenylated indole alkaloids using LC-MS/MS with thespectrometry aim of developing a methodology for the rapid identification of prenylated indole alkaloids is an effective method. This technique has been used as an analytical tool for the in microbial extracts. Results and Discussion characteristics of prenylated indole alkaloids using LC‐MS/MS with the aim of developing a methodology for the rapid identification of prenylated indole alkaloids in microbial extracts
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