Abstract
Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1–4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1–4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.
Highlights
Marine organisms have been attractive targets of novel drug discovery for decades [1]
One is is cholesterol cholesterol sulfate, sulfate, and and we previously reported its mode of inhibition with an IC50 molecules
Optimized geometries and chemical shifts calculated at the polarizable continuum model (PCM)(DMSO)‐B3LYP/6‐311++G(d,p) level are summarized in Figure 4 and Table 2
Summary
Marine organisms have been attractive targets of novel drug discovery for decades [1]. As a result of this work, several drugs based on natural products and derivatives have been approved for clinical treatments. The USFDA has approved seven drugs derived from marine organisms so far, successthis rate, out ofrate, 28,000 marine products, be taken organisms so far,this success outregistered of 28,000 registered marine can products, canfavorably be taken relative torelative terrestrial products [3]. C previously virus, we reported the possibility of coral reef organisms as a source for new antivirals [4]. Among the previously reported the possibility of coral reef organisms as a source for new antivirals [4]. 61 61 marine organisms, we star the extracts prepared from marine organisms, wefound foundthat thataalipophilic lipophilicextract extract of of the feather star.
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