Abstract
Objectives: The aim of the present research is to prepare mouth dissolving film of aprepitant used in the prevention and treatment of post-operative nausea and vomiting.
 Methods: The MDF was prepared using Kollicoat IR, PEG 400, and spraying technique. Formulation was optimized by central composite design. Compatibility study was carried out using Fourier-transform infrared and differential scanning calorimetry. The films were evaluated for thickness, folding endurance, weight variation, disintegration time, dissolution studies, drug content, and in vitro diffusion test.
 Results: From the results, it was found that there was no drug excipient interaction. The prepared optimized batch AP2 showed disintegration time 18 sec, highest dissolution rate 101.53%, drug diffused 39.58 mg/cm2 within 10 min and also passes all the physicochemical parameters. It was concluded that plasticizer PEG 400 plays a very much important role in the preparation of aprepitant MDF.
 Conclusion: MDF of aprepitant was found to be a better option in the prevention and treatment of post-operative nausea and vomiting by the way of fast onset of action for patient convenience and compliance. In the near future, the MDF market will expand very fastly to treat various diseases.
Highlights
Oral delivery is currently the gold standard in the pharmaceutical industry, where it is regarded as the safest, most convenient, and most economical method of drug delivery having the highest patient compliance
The physical mixture of aprepitant and excipients was subjected to Fourier-transform infrared (FTIR) to identify any interaction between them
Aprepitant MDFs were prepared by spraying technique using Kollicoat IR and PEG 400
Summary
Oral delivery is currently the gold standard in the pharmaceutical industry, where it is regarded as the safest, most convenient, and most economical method of drug delivery having the highest patient compliance. The problem associated with oral route of administration is first-pass metabolism, drug degradation in variable pH condition of gastrointestinal tract, inadequate absorption, slow onset of action, and drawbacks related to particular class of patients which includes geriatric, pediatric, and dysphagia patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. To overcome these issues, fast dissolving drug delivery systems are gaining considerable attention. To protect the dosage form and to overcome such problems, new technology was developed as fast dissolving oral films [1,2,3,4,5,6]
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