Abstract
Effective assessment and management of wound pain can facilitate both improvements in healing rates and overall quality of life. From a pharmacological perspective, topical application of nonsteroidal anti-inflammatory drugs in the form of film wound dressings may be a good choice. Thus, the aim of this work was to develop novel layered film wound dressings containing ibuprofen based on partially substituted fibrous sodium carboxymethylcellulose (nonwoven textile Hcel NaT). To this end, an innovative solvent casting method using a sequential coating technique has been applied. The concentration of ibuprofen which was incorporated as an acetone solution or as a suspension in a sodium carboxymethylcellulose dispersion was 0.5 mg/cm2 and 1.0 mg/cm2 of film. Results showed that developed films had adequate mechanical and swelling properties and an advantageous acidic surface pH for wound application. An in vitro drug release study implied that layered films retained the drug for a longer period of time and thus could minimize the frequency of changing the dressing. Films with suspended ibuprofen demonstrated higher drug content uniformity and superior in vitro drug release characteristics in comparison with ibuprofen incorporation as an acetone solution. Prepared films could be potential wound dressings for the effective treatment of wound pain in low exuding wounds.
Highlights
The European Wound Management Association (EWMA) Position Document acknowledges that pain is a major issue for patients with acute and chronic wounds [1]
Films prepared from NaCMC possess all these characteristics and were chosen for the preparation of film dressings with ibuprofen
Substituted microfibrous NaCMC was used in order to increase the mechanical resilience of the films after wetting
Summary
The European Wound Management Association (EWMA) Position Document acknowledges that pain is a major issue for patients with acute and chronic wounds [1]. Pain produces stress, which can affect individuals in both psychological and physiological ways and results in delayed wound healing and detrimental effects on quality of life [2]. Effective assessment and management of wound pain could facilitate an improvement in healing rates and overall quality of life. Wound-related pain can be temporary (acute) or persistent (chronic) [3]. Acute wound pain can be exacerbated whenever the wound is handled or manipulated: during dressing removal, wound cleansing, or debridement (removing of necrotic tissues). Persistent (chronic) wound pain is the background symptom that exists at rest and between wound-related procedures
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