Formulation of Compressed Lozenges from Decaffeinated Arabica Green Coffee (Coffea arabica L.) Bean Extract as Immune Booster

Abstract

Global public health issues include emerging and reemerging viruses. The most recent cause of COVID-19 is the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The main goal of current medical research is the creation of new, affordable, and effective anti-COVID-19 medications. The immune system regulates coronavirus infection in the human body. The current study explores the relationship between antioxidants and the immune system’s ability to fight off infections and the pathogenicity of the coronavirus. Arabica coffee contains chlorogenic acid, which is efficacious as a contributor to antioxidant and antiviral activity. But arabica coffee also contains caffeine, which can cause ulcers in people who do decaffeination using dichloromethane solvent to reduce levels of caffeine. The objective of this study is to create Arabica coffee seed extract compressed lozenges as an antioxidant to boost the immune system. Arabica coffee extraction is done by Soxhletasi. Formulation lozenges are made in three formulas with varying types of flavorings: F1 (strawberry), F2 (tiramisu), and F3 (vanilla). Lozenges were analyzed using HPLC with pretreatment SPE to see the effect of the formulation on the content of caffeine and chlorogenic acid. F1 caffeine content 1.324%, 4.484% F2, F3 0.134. F1 chlorogenic acid content 2.996%, 2.834% F2, F3 4.530% .The result of the granules and lozenges evaluation is required for the granules and lozenges requirements. As a result of hedonic stimulation, the respondent can receive a taste of lozenges. Formula lozenges which most preferred is the formula F1 with strawberries creamer diluent with caffeine content of 1.324% and chlorogenic acid content of 2.996%. The conclusion of this study is that green coffee bean extract can be made into lozenges, and caffeine levels in coffee can be reduced by decaffeination. but the level of chlorogenic acid decreased along with the decrease in caffeine.