Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone.

Leire Ruiz-Rubio,Vitaliy Khutoryanskiy,María Alonso,Rosa Alonso,Jose Vilas,Leyre Pérez-Álvarez

doi:10.3390/polym10020175

Leire Ruiz-Rubio, Vitaliy Khutoryanskiy + Show 4 more

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https://doi.org/10.3390/polym10020175

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Journal: Polymers	Publication Date: Feb 11, 2018
Citations: 29	License type: CC BY 4.0

Affiliation: University of the Basque Country, University of Reading

Abstract

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Highlights

The development of dosage forms containing poorly-water soluble drugs remains a challenging task for formulation science
We evaluated swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations based on different Carbopols® and poly(2-ethyl-2-oxazoline)s of different molecular weights in vitro
The yield of different interpolymer complexes formed for each combination of the 974 and 971 Carbopols with POZ of different molecular weights have been studied both in water and at pH 2 (Figure 1)

Summary

Introduction

The development of dosage forms containing poorly-water soluble drugs remains a challenging task for formulation science. Polyethylene glycols (PEGs) have been widely used to formulate poorly-water soluble drugs [4] and in other pharmaceutical applications [5]. The main advantages of POZs include: they are easy to synthesize; they do not form peroxides; and they are stable at room temperature and in water. They could be cleared from the body and are not excessively hydroscopic [11,12,13]. Poly(2-oxazoline)s are highly versatile materials with a capability to form functional materials and structures depending

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