Abstract
In the present study bilayer patch of benzydamine HCl was developed using solvent casting method. Different substrates were attempted like Petri dish, glass-and-ring, and teflon-and-ring for selection of the proper option to formulate patch that should give easily peelable film with adequate mechanical properties. HPMC E15 LV was used in different concentrations for obtaining proper viscosity of solution for pouring on to surface and ring, that it should not leak from ring. The second layer was optimized by using different polymer like eudragit RSPO, eudragit RSPO + EC, and eudragit NE30 D for efficient layer bonding. The minimum release from backing membrane was established by diffusion study as compared to from drug loaded layer. The optimized batches were evaluated for folding endurance, weight variation, thickness, drug content, drug release, tensile strength, layer separation, mucoadhesion, moisture uptake, and layer bonding. The novel gingival patch of benzydamine HCl developed would be beneficial in optimizing the therapy.
Highlights
The concentration of drugs, when taken orally or by intramuscular route, in the blood increases and reaches its peak value in few minutes to hours
Batches from DL4–DL6 were of combination of ethyl cellulose and eudragit RSPO with different concentration of TEC as plasticizer
It could be concluded that periodontal bilayered patches of benzydamine HCl were formulated by solvent casting technique using teflon coated iron and ring
Summary
The concentration of drugs, when taken orally or by intramuscular route, in the blood increases and reaches its peak value in few minutes to hours. In conventional mode of administration, many drugs do not reach the target area in the body in sufficient concentration because many are prematurely inactivated and excreted This problem can be overcome by administering the drugs directly into the intended site of action with lesser dose, discussed by Venkatesh, Jain [3, 4]. Discussed by Raghavendra Rao, Poddar [5, 6], Nonsteroidal Anti-Inflammatory Drugs (NSAID) have been widely used for their application in dentistry which consists of analgesic and anti-inflammatory effects [6]. These drugs are used for relieving pain in periodontal disease and retarding the disease process. NSAID act by inhibiting inflammatory enzymes triggered by cytokines, which are important immune factors in periodontal disease
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