FORMULATION OF ANTI-ACNE GEL OF MORINGA OLIEFERA LEAVES POWDER ETHANOLIC EXTRACT AS AN INHIBITOR OF BACTERIA

Abstract

Acne (Acne vulgaris) is the most common disorder which is a chronic inflammatory disease. That cause acne by one of the bacteria is staphylococcus epidermis. Moringa oleifera leaves contain flavonoid, alkaloid and phenolic compound which have inhibit acne growth. The purpose of the study is the compression of bacteriostatic ability of the extracts and gel for formula that can fulfills the physical properties of good gel moringa leaves. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 as a polymer were used extract was added with variation concentration of 5,10,15% physical evaluation test of gel was organoleptic, homogeneity, PH, viscosity, adhesion, and spread tests for 4 weeks. In-vitro bacteriostatic activity test with 1% Clindamycin gel a positive control and polymer gel negative control. The results that variation concentrations of ethanol extract of moringa leaves affected the physical properties of gel including viscosity PH, adhesion and spread ability. KEYWORDS: Moringa oleifera, Acne vulgaris, clindamycin, HPMC4000