Abstract
The mouth dissolving tablets are prepared and formulated utilizing different additives like plasticizers, polymers and other bulk forming agents. There are many different batches are manufactured and tested for their evaluation parameters like disintegration test, dissolution test, content uniformity test and weight variation tests. The many bateches are tested and one of the optimized batch is selected for pharmacological action and marketing purpose. The analytical method was developed as according to calibration curve. Oral dispersible tablets of perampenal have been prepared and formulated utilizing xanthen gum and super disintigrant sodium crosscarmilose and sodium starach glycolate with crospovidone with multi-stationary punching machine. The phosphate buffer is also utilized for mainting buffer pH of the intestine. The natural polymers are preffered as compared to synthetic polymers. The different batches of tablets have been prepared and evaluated with official dissolution time, disintegration time, weight variation and content of uniformity tests and unofficial firability testing with Roche friabilator and hardness or tensile strength of the the prepared tablets with Pfizer hardeness tester. Keywords: Perampanel, xanthen gum, crosscarmilose, crosspovidone, sodium starch glycolate, mouth dissolving tablets
Published Version
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