Abstract
Dicyclomine hydrochloride have major problem to its bitter taste. Due to its bitter taste pediatric and geriatric patients have less acceptability. The objective of present work was preparation and evaluation of chewable tablets of Dicyclomine hydrochloride by using Ion exchange resin for taste masking. Taste masking of Dicyclomine HCl was done by using weak cation exchange resin such as Tulsion 335 and Kyron T 159. When comparing drug loading capacity it noticed that Tulsion 335 showed high drug loading as compared to Kyron T 159 at 1: 5 drug –resin ratio. Maximum drug bounding was observed with 90 min swelling time and 90 min stirring time. Manufacturing of chewable tablet was done by direct compression method. In this formulation various excipients were used such as crospovidone as disintegrant, mannitol as a diluent, Sucralose as sweetener The powder blend and tablet formulation was evaluated for precompression and post compression study respectively. The results have shown maximum drug loading was obtained using Tulsion 335 as ion exchange resin in the ratio of 1:5 (drug: resign). Taste masking was evaluated with invitro threshold value.
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