Abstract
99mTc labelling of DMSA under moderate reduction conditions (alkaline pH and low concentration of Sn(II) leads to formation of various DMSA complexes. One of them 99mTc(V)-DMSA is proved to be suitable for tumour imaging in nuclear medicine diagnostics. The aims of our study were to define the optimum terms for high yield of 99mTc(V)-DMSA complex and kit formulation, which can be conveniently applied for diagnosis in nuclear medicine laboratories. The 99mTc labelled DMSA complexes were analysed by means of ascending thin layer chromatography (TCL) in three mobile phases - methyl ethyl ketone, n-butanol/acetic acid/water 3/2/3 and 0.154 M NaCl. Appropriate formulae were chosen for kit preparation and applied for preliminary clinical investigations.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call