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Abstract
An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, taste masking and characterized using XRPD and IR. Using resinate sustained release tablets were formulated using hydoxypropylmethylcellulose K100M.The tablets were evaluated for hardness, thickness, friability, drug content, weight variation and in vitro drug release. Tablets thus formulated (Batch B-6) provided sustained release of drug over a period of 10 h with first order kinetics. The release of metformin HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that metformin HCl was successfully taste masked and formulated into a sustained dosage form as an alternative to the conventional tablet.
Highlights
An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264
In the present work strong cation exchange resins i.e. Indion 244 and Indion 264 were employed in order to get the sustained release profile of metformin hydrochloride
Metformin hydrochloride was loaded on ion exchange resin by batch process
Summary
An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. Synthetic ion exchange resins have been used in pharmacy and medicine for taste masking or controlled release of drug as early as 1950[5,6]. Determination of drug content in the resinate: An accurately weighed amount of drug equivalent resinate (0.1 g) was dissolved in 100 ml of 0.1N HCl and stirred for 5 h.
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