Abstract
Ondansetron hydrochloride is an intensely bitter antiemetic drug used to treat nausea and vomiting following chemotherapy. The purpose of the present work was to mask the taste of ondansetron hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using indion 234 (polycyclic potassium with carboxylic functionality) and an ion-exchange resin was used to mask the bitter taste and then the taste-masked drug was formulated into an orodispersible tablet (ODT). The drug loading onto the ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug to resin and temperature. The resinate was evaluated for taste masking and characterized by X-ray diffraction study and infrared spectroscopy. ODTs were formulated using the drug–resin complex. The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in vitro and in vivo disintegration time and in vitro drug release. The tablets disintegrated in vitro and in vivo within 24 and 27 s, respectively. Drug release from the tablet was completed within 2 min. The obtained results revealed that ondansetron HCl has been successfully taste masked and formulated into an ODT as a suitable alternative to the conventional tablets.
Highlights
Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms
More than 50% of the pharmaceutical products are orally administered for several reasons, and undesirable taste is one of the important formulation problems encountered with such oral products
Taste of a pharmaceutical product is an important parameter for governing compliance
Summary
Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms. More stress is laid down on the development of an organoleptically elegant and patientfriendly drug delivery system for pediatric and geriatric patients.[1,2] More than 50% of the pharmaceutical products are orally administered for several reasons, and undesirable taste is one of the important formulation problems encountered with such oral products. Taste of a pharmaceutical product is an important parameter for governing compliance. Taste masking of oral pharmaceuticals has become an important tool to improve patient compliance and the quality of treatment, especially in pediatrics. Formulation of taste-masked products is a challenge to the pharmacists.[3,4]
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