FORMULATION AND EVALUATION OF TDDS OF DICLOFENAC SODIUM CONTAINING NATURAL PENETRATION ENHANCER

Abstract

Transdermal drug delivery system is the system in which the delivery of the active ingredients of the drug occurs through the skin. Transdermal drug delivery system can improve the therapeutic efcacy and safety of the drugs because drug delivered through the skin at a predetermined and controlled rate. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. The present investigation was aimed to prepare, characterize and evaluate transdermal matrix patches, Diclofenac Sodium for non-steroidal anti-inammation and pain related disease. Based on results of various evaluation parameters like thickness, strength, elongation, better compatibility and stability the transdermal matrix patches was successfully designed and developed by trial and error method and evaluated for physicochemical parameters like thickness, weight variation, moister content, and drug content value. Transdermal matrix patched ware papered by using different concentration of ethyl cellulose. And it was concluded that the concentration of polymer increase the thickness of patches weight uniformity and folding endurance increase.