Abstract
The present study was focused on a poorly aqueous soluble drug (diacerein); basic structured anthracene molecule possesses defensive activity against osteoarthritis. The problem with the diacerein is its poor bioavailability (35%) which is due to its poor dissolution profile. The present study efforts to improve the dissolution profile using solubility enhancement techniques. The objective of the study was to improve the solubility of poorly soluble drug diacerein by solid dispersion technique and inclusion complex using the most compatible carriers and technique for the formulation. The prepared solid dispersion and inclusion complex were evaluated for physiochemical characteristics and dissolution efficacy. Thesolid dispersion and inclusion complex were formulated using kneading method with PVP K30 (screened to be the best among different carriers) and β-cyclodextrin respectively. The prepared formulations were characterized by FTIR, SEM, DSC and XRPD. The prepared solid dispersion and inclusion complex were then compressed into conventional tablets which were then coated with acid resistant polymer.
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