Abstract
The purpose of this research is to design and formulate the Self-micro emulsifying drug delivery system (SMEDDS) of poorly water-soluble drug Sertraline Hydrochloride (SRT). SRT is commonly used selective serotonin reuptake inhibitor for the management of a number of depressive disorders. Its applicability is limited because of extensive metabolism and poor oral bioavailability of 44 %. Solubility of SRT in different vehicles is determined with the help of which ternary phase diagrams were constructed. Capmul MCM C8 EP (as oil phase), Cremophore RH 40 (as surfactant) and Labrafil M 2125 CS (as co-surfactant) were selected for development of liquid (SMEDDS) formulation. The prepared system was characterized for globule size, TEM, transmittance study, stability analysis and permeability. The formulation was converted to solid by adsorption on Neusilin US2 to convert the system into tablet the most convenient route. Results of evaluation and characterization of formulated T SMEDDS of SRT were compared with those of pure drug. In-vitro dissolution study and comparison to that of marketed formulation indicates that Tablet of this formulation helps to improve the solubility.
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