Formulation and Evaluation of Pravastatin Sodium Rapid Dissolving Films Using Various Hydrophilic Polymers

Abstract

The current availability of a variety of novel oral administration technologies has enabled more effective pharmacokinetic and physicochemical investigations along with improved patient compliance. Typical solid-dosage formulations were replaced with rapid-dissolving films. An oral film dosage form that dissolves or disintegrates quickly in the mouth without the need for water is referred to as an "oral rapid dissolving film." The main objective of this study was to use the solvent casting method to explore rapid dissolving films of Pravastatin sodium using certain hydrophilic polymers, such as various grades of HPMC, PVA, and Ocimum basilicum mucilage powder. Various evaluation parameters were performed to the prepared films, including appearance, weight variation, thickness, folding endurance, moisture uptake, content homogeneity, and an in vitro disintegration and dissolution test. For stability testing, the optimized formulation was kept. The FTIR data revealed that there was no incompatibility between the medication and the polymers, and that all of the parameters were within the acceptable limits. FP9 (PVA 0.5%, OB 1.5 %) disintegrated the fastest of all the formulations, and the films remained stable. As a result, it may be stated that the Pravastatin sodium rapid dissolving films are possibly effective in treatment of hyperlipediemia with a rapid onset of action.