Abstract
Piroxicam is an analgesic, antipyretic and anti-inflammatory effects drugs, used to reduce pain, swelling joint stiffness from osteoarthritis, rheumatoid arthritis and by inhibiting prostaglandin synthetase. In the research work, seven formulations (F1 to F7) were prepared direct compression method by using 3 superdisintegrants namely Crospovidone, Crosscarmellose sodium and Sodium starch glycolate in two ratio (1:0.5 and 1:1) and F7 (without superdisintegrant). All the formulations evaluated various post compression parameters thickness, weight variation, disintegration time, hardness, friability, wetting time, drug content water absorption ratio and in- vitro dissolution studies. The best formulation was studied anti-inflammatory activity in rats by using the paw-edema method. Among all formulations (F1) which contains 1:0.5ratio of Croscarmellose sodium, showed to be the optimized formulation as it give good wetting time (51.66 sec), fast disintegration time (29.16 sec), maximum drug release of 99% within 30 minutes and superior anti-inflammatory activity.
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