Abstract
Methanolic extract of Bombax buonopozense was evaluated for possible anti-nociceptive, antiinflammatory and anti-pyretic activities in mice and rats. Acetic acid-induced abdominal constriction test in mice and formalin test in rats were used to investigate the antinociceptive effect of the extract. Studies were carried out on yeast-induced pyrexia and egg albumin-induced anti-inflammatory activity in rats. The extract produced a significant decrease in acetic acid-induced writhing in mice and inhibition of late phase of the formalin pain test in rats. The methanolic extract of B. buonopozense leaf also produced a potent antipyretic effect and significant inhibition of egg albumin-induced antiinflammatory activity in rats. The result suggests that B. buonopozense contains biologically active substances with potential values for the treatment of fever, painful and inflammatory conditions. Keywords : Bombax buonopozense; analgesic, inflammation, pyrexia.
Highlights
Due to the limitations of opioid and non-steriodal antiinflammatory drug (NSAID) therapy, there is a continuous search for new analgesic
The pre-screened albino mice employed for this study were divided into five groups of six each (n = 6) and pre-treated as follows: Groups I, II and III received 25, 50 and 20 mg/kg of the extract, respectively; group IV received 150 mg/kg of acetylsalicylic acid (ASA) and group V which served as the control, received distilled water in appropriate volumes, all were administered i.p
The results show that B. buonopozense significantly (P < 0.05) and dose-dependently reduced the number of acetic acid-induced abdominal constrictions in mice
Summary
The individual leaflets have entire margins and are large. Clous (Beentje and Sara, 2001). It is widely distributed in Africa, from Ghana to Sierra Leone, Uganda and Gabon. A decoction of the leaves is used for feverish conditions, pains and muscle aches. Due to the limitations of opioid and non-steriodal antiinflammatory drug (NSAID) therapy, there is a continuous search for new analgesic. In view of this and on account of the usefulness of some painful and inflammatory conditions which has not been scientifically verified, this current study was aimed at investigating possible antinociceptive, anti-inflammatory and antipyretic activities of.
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