Abstract
Pentoxifylline-loaded poly(ε-caprolactone) microspheres were prepared by solvent evaporation technique with different drug to carrier ratio F1 (1:3), F2 (1:4), F3 (1:5) and F4 (1:6). The microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, percentage yield, drug entrapment, stability studies and for in vitro release kinetics. The shape of microspheres was found to be spherical by SEM. The size of microspheres was found to be ranging 59.3±6.3μm to 86.22±4.23 μm. Among the four drug to carrier ratio, F3 (1:5) showed maximum percentage yield of 83.34±2.46% and F2 (1:4) showed highest drug entrapment of 76.92±3.24% w/w. It was found that there was no interaction between drug and polymer by FT-IR study. No appreciable difference was observed in the extent of degradation of product during 60 d in the microspheres, which were stored at various temperatures. In the in vitro release study formulation F2 (1:4) showed 90.34% drug release at 15 h and found to be sustained. The release followed Higuchi kinetics indicating diffusion controlled drug release.
Highlights
Pentoxifylline-loaded poly(ε-caprolactone) microspheres were prepared by solvent evaporation technique with different drug to carrier ratio formulation was 1:3 (F1) (1:3), F2 (1:4), F3 (1:5) and F4 (1:6)
Kinetics of drug release: In order to understand the mechanism and kinetics of drug release, the result of the in vitro dissolution study of microspheres were Þtted with various kinetic equations, like zero order[20]
Poly(є-caprolactone) microspheres of pentoxifylline were prepared by solvent evaporation technique
Summary
Nandha College of Pharmacy, Perundurai Main Road, Erode-638 052; 1Department of Pharmacy, Barakatullah. Pentoxifylline-loaded poly(ε-caprolactone) microspheres were prepared by solvent evaporation technique with different drug to carrier ratio F1 (1:3), F2 (1:4), F3 (1:5) and F4 (1:6). The microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, percentage yield, drug entrapment, stability studies and for in vitro release kinetics. In the in vitro release study formulation F2 (1:4) showed 90.34% drug release at 15 h and found to be sustained. Of the various biodegradable polymers used for the development of sustained release formulations, poly(є-caprolactone) has been reported to be advantageous since they are biocompatible 7,8. Poly(є-caprolactone) is aliphatic polyester polymer, suitable for controlled drug delivery due to a high permeability to many drugs and at the same time being free from toxicity[9,10]. Pentoxifylline, a xanthine derivative, is an analogue of theophylline and inhibits phosphodiesterase
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