Abstract
Delayed release microspheres of Aceclofenac were formulated using an enteric polymer, cellulose acetate phthalate prepared by solvent evaporation technique. The effects of various other modern enteric polymers such as hydroxyl propyl methyl cellulose phthalate, Eudragit L 100 and Eudragit S -100 on the release of Aceclofenac from the CAP microspheres have been evaluated. The microspheres were characterized for particle size, shape, percentage yield, drug entrapment, and for in-vitro release kinetics. The shape of microspheres was found to be spherical by SEM. The size of microspheres was found to be ranging 8.84 ± 0.14 to 11.2 ± 0.18. The study was designed in the form of a factorial design in which the effects of HPMCP, Eudragit L 100 and Eudragit S 100 on the release rate of CAP delayed release microspheres were calculated. The results revealed that the HPMCP exhibits positive influence whereas Eudragit L 100 and Eudragit S 100 exhibits negative effect on the drug release rate of CAP microspheres. In-vitro drug release from all formulations followed the first order release kinetics and erosion plot.
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