Formulation and Evaluation of Patch Preparations for Respiratory Relief from a Blend of Extracts and Essential Oils of Ginger Rhizome

Abstract

In this study, pharmaceutical preparations for respiratory tablets in the form of patches have been developed, which are used by placing them on the skin, clothes or masks associated with the user. A patch formula containing a mixture of 3% ginger extract and ginger essential oil was created at 0.1%, 0.2% and 0.3%, respectively, with variations of PVA and PVP as polymers to control the release of ginger essential oil as a breathing reliever. Each preparation with ginger essential oil content used PVA and PVP with variations of 1:1, 1:1.5 and 1:2. The practices were evaluated for 21 days on days 0, 7, 14, and 21. TAfter obtaining long-lasting results, an irritation test was carried out on the respondents. The results showed that during storage for 21 days, the pH was in the range of 5.14-6.11, weight uniformity ranged from 1.24 g-1.65 g, humidity 7.18%-8.88%, and folding endurance >300 times. The variation of PVA and PVP shows that the higher the PVP content, the weight of the patch increases and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%. After obtaining long-lasting results, an irritation test was carried out on the respondents. The results showed that during storage for 21 days, the pH was in the range of 5.14-6.11, weight uniformity ranged from 1.24 g-1.65 g, humidity 7.18%-8.88%, and folding endurance >300 times. These alterations, do not change color and odor nor irritate the respiratory tract. The variation of PVA and PVP shows that the higher the PVP content, the weight of the patch increases, and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%; the weight of the patch increases, and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%.