Abstract
Objective: The objective of the present study was formulation and evaluation of new medicated chewing for the treatment of nausea and vomiting induced by chemotherapy, radiation therapy, and post-operative conditions in cancer using ondansetron hydrochloride as drug candidate.
 Methods: The medicated chewing gum of ondansetron hydrochloride (OHC) was prepared by direct compression mold method. Four formulations were selected for study which was showing good physicochemical properties and drug release. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, estimation of chewing gum consistency and drug release study in saliva.
 Results: All the formulations gave satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation medicated chewing gum II (MCG II) showed best in vitro drug release which is 97% in 30 min and it is also more accepted by the people. Drug release in saliva also indicated that more than 50% drug release occurs within 15 min.
 Conclusion: Medicated chewing gum is a cost-effective product and also showed better compliance and increase in bioavailability.
Highlights
Medicated chewing is a new drug delivery system for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV), radiation therapy-induced nausea and vomiting (RINV), and in postoperative nausea and vomiting (PONV) conditions
Formulation medicated chewing gum II (MCG II) was selected as optimized formulation for making medicated chewing gums, where ascorbic acid was used as antioxidant, dextrose was used as sweetening agent as well as bulking agent, beeswax/PVP as elastomer and gum, peppermint oil was used as flavoring agent
ondansetron hydrochloride (OHC) is completely absorbed by GIT which makes this as a choice of drug in preparing medicated chewing gum of OHC
Summary
Medicated chewing is a new drug delivery system for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV), radiation therapy-induced nausea and vomiting (RINV), and in postoperative nausea and vomiting (PONV) conditions. Drugs are usually formulated in variety of dosage forms like tablets, capsules, injections, inhalers and ointments etc. The oral drug delivery system is most acceptable route of drug administration due to ease of administration than other dosage forms. Medicated chewing gums are used to deliver drug locally or systemically. Drug can be release locally for the oral treatment or may be absorbed rapidly by oral mucosa for systemic conditions, leading to fast onset of action and bioavailability. This avoids first-pass metabolism and metabolism in gastrointestinal tract [1,2,3,4,5,6,7]
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