Formulation and Evaluation of Herbal Anticancer Chewing Gum

Abstract

The objective of the present study is the formulation and evaluation of herbal anticancer Chewing gum. Cancer is the abnormal growth of cells in the body. With emerging trends in herbal medicine and complementary alternative medicine, India is considered one of the world's largest producers of herbal medicine. Many plants and their products have anticancer agents. Ginger is considered an important spice with many clinical potential activities. Ginger and its compounds display anti-inflammatory, antioxidant, antimetastatic, and anticancer activity. The anticancer activity of ginger components is reviewed in this article due to its versatile therapeutic nature. The medicated chewing gum of gingerol was prepared by direct compression mold method. Five formulations were selected for study which was showing good physicochemical properties and drug release. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, estimation of chewing gum consistency, and drug release study in saliva. All the formulations showed satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation medicated chewing gum 2 (F2 Batch) showed the best in-vitro drug release of 96% in 30 min and it is also accepted by people. Drug release in saliva also indicated that more than 50% of drug release occurs within 15 min. Medicated Chewing Gum is cost-effective and also shows better compliance with an increase in bioavailability.