Formulation and Evaluation of Natural Excipient-based Mucoadhesive Salbutamol Sulphate Tablets

Abstract

When creating a mucoadhesive sustained-release formulation for oral consumption, aquaphilic matrices are a captivating option to consider. These aquaphilic matrices are used to release water-soluble and water-insoluble drugs. Gums and mucilages used in the current study are linseed mucilage (LM) and tamarind seed polysaccharide (TSP). The present work aims to focus on the possibilities of using these polysaccharides to prepare a new medication delivery system. The aim of the research was to make a salbutamol sulfate mucoadhesive tablet for the treatment of asthma. The wet granulation method was adopted for the formulation of the salbutamol sulfate mucosal adhesive tablet. Mucosal adhesive tablets were assessed for multiple parameters. The drug release is low as the amount of gums and mucilages is high. A mucoadhesive tablet containing linseed mucilage and chitosan exhibits good mucoadhesive performance and in-vitro drug release. Optimized formulation FM1 fits the Higuchi plot of release kinetics