Formulation and evaluation of microemulsion containing ketoprofen

Abstract

Ketoprofen microemulsion is presently considered as the novel drug delivery system. It shows prolonged action. Ketoprofen is a BCS II class drug. It is a highly lipophilic poorly soluble drug with low oral bioavailability. The present aim was to increase the solubility by a microemulsion system for topical delivery. Microemulsions are clear, stable and isotropic liquid. They show advantages such as spontaneous preparation, scale up, ease of preparation, improving drug solubility of hydrophobic drugs. It is also used to increase the bioavailability of drug. These also aim at controlling the bioavailability of various drug molecules. The review put forward the development in a microemulsion-containing system. They improve solubility, chemical stability and oral bioavailability of poorly water-soluble drugs. There is a formulation of four different batches. The batches differ in the quantity of surfactant and co-surfactants.