Formulation and evaluation of microemulsion containing griseofulvin

Abstract

The aim of the following research is to formulate a microemulsion containing drug Griseofulvin. Griseofulvin is an antifungal agent which inhibits the mitosis. It is recommended orally for treatment of fungal disease. It is used to treat skin infections such as jock itch, athletes foot and ringworm. Also it is used to treat the fungal infections of scalp, toenails and fingernails. Griseofulvin is a BCS II class drug. It is highly lipophilic poorly soluble drug with low oral bioavailability. The present aim was to increase the solubility by microemulsion system for topical delivery. Microemulsions are clear, stable and isotropic liquid. They show advantages such as spontaneous preparation, scale up, ease of preparation, improving drug solubility of hydrophobic drugs. It is also used to increase the bioavailability of drug. These also aim at controlling the bioavailability of various drug molecules. The review put forward the development in microemulsion containing system. They improve solubility, chemical stability and oral bioavailability of poorly water soluble drugs. There is formulation of four different batches. The batches differ in quantity of surfactant and co- surfactants.