FORMULATION AND EVALUATION OF KETOROLAC TROMETHAMINE EMULGEL

Abstract

Emulgel has emerged united of the foremost intriguing topical delivery techniques because of its twin unleash mechanism, that contains each gel and emulsion. Topical drug applications provide a variety of benets, including the ability to transport medicine to the site of action and keep it there for a prolonged period of time. The primary purpose of this formulation is to enhance the topical dispersion of a hydrophobic drug (Ketorolac tromethamine). Carbopol 974P NF, eudragit S100 and Sodium CMC are a gelling agent used in a Ketorolac tromethamine emulgel. The emulgel was created with liquid parafn because the oil, span 80 because the emulsier agent. Physical look, pH, drug content, in-vitro diffusion investigations, and a skin irritation check were all performed on the ready emulgels. In-vitro diffusion studies disclosed that formulation EF6 discharged 97.89 % of the drug once 10 hours, with the results indicating that formulation EF6 discharged the drug loads of effectively than various formulations. In ex-vivo diffusion studies, EF6 discharged 97.92 % of the drug in 12 hours. Albino Wistar Rats were studied for their antiinammatory (carrageenan-induced paw edema) and analgesic (hot plate latency test) properties.