Abstract
Aim: The goal of the study was to prepare a superdisintegrant named starch malonate followed by its evaluation for physicochemical properties. Prepared starch malonate was optimized in the preparation of fast dissolving tablets of ibuprofen by using 23 factorial designs.
 Methods: Compatibility studies like FTIR, TLC and DSC were performed to check any interaction between starch malonate and ibuprofen. Fast dissolving tablets were compressed by direct compression method and subjected to various official tests like hardness, friability, drug content, dissolution etc. Wetting time and water absorption ratio were also performed. At last response surface plot and contour plot was plotted to check the effects of starch malonate, croscarmellose sodium and crospovidone (independent variables) on disintegration time and dissolution efficiency in 5 minutes (dependent variables). Stability studies were also performed to check the stability of prepared fast dissolving tablets of ibuprofen.
 Results: Results of the studies showed that all the results are within acceptable limits and complying with the criteria of fast dissolving tablets. Drug content was found to be (100±5%), hardness of all tablets were found in between 3.8 -4 kg/cm2, friability was found less than 0.15%. Optimized formulation has showed less wetting time, less disintegration time followed by enhanced drug release. Among all formulation, formulation F2 has shown least disintegration time and enhanced drug release (99.89%) as compared to other formulations. We can conclude that starch malonate can be used as a novel superdisintegrant.
Highlights
Drugs solubility is the important and critical step in the formulations of any dosage form
They are named “fast dissolving systems” as they are characterized by their property to disintegrate within seconds as soon it comes in contact with saliva which results in fast release of drugs
In this current work our main aim is to prepare novel modified starch named starch malonate by esterification reaction which will be used as superdisintegrant in order to enhance the drug release of poorly soluble drug
Summary
Drugs solubility is the important and critical step in the formulations of any dosage form. Literature study has shown that conventional oral solid dosage forms (tablets or capsules) has shown the problem of swallowing, dysphasia (nausea), chocking and its difficult to administer to mentally ill, bed-ridden and unconscious patients [5]. To overcome these problems fast dissolving systems are in boom. They are named “fast dissolving systems” as they are characterized by their property to disintegrate within seconds as soon it comes in contact with saliva which results in fast release of drugs. Concentration of starch malonate alone or in combination with other known superdisintegrant (Croscarmellose sodium, Crospovidone) are optimized by using 23 factorial designs and fast dissolving tablets of Ibuprofen was prepared
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