Abstract
Objective: The objective of the present research was to prepare starch phthalate (a novel super disintegrant) and to optimize and formulate ibuprofen fast dissolving tablets employing 23factorial design using starch phthalate as super disintegrant.
 Methods: Drug excipient compatibility studies like Fourier-transform infrared spectroscopy (FTIR) and thin-layer chromatography (TLC) studies were carried out to check the drug interaction between ibuprofen and starch phthalate. Direct compression method was used for tablet preparation. Prepared tablets were then evaluated for hardness, friability, drug content, disintegration time, water absorption and wetting time, in vitro dissolution studies. Response surface plots and contour plots were also plotted to know the main effects and interaction effects of independent variables (starch phthalate (A), croscarmellose sodium (B) and crospovidone (C)) on dependent variables (disintegration time and drug dissolution efficiency in 1 minute) and stability studies were also done.
 Results: Tablets of all formulations were of good quality concerning drug content (100±5%), hardness (3-6 kg/cm2), and friability (less than 0.16%). In all formulations, formulation F5 found to be optimized formulation with least disintegration time 20±0.28 seconds, less wetting time 09±0.12 seconds and enhanced dissolution rate in one minute, i.e., 91.95±0.22 as compared to other formulation.
 Conclusion: From the research, it was concluded that on combination with crospovidone, starch phthalate enhanced the dissolution efficiency of the drug. Hence, starch phthalate can be used as a novel disintegrant in the manufacturing of fast dissolving tablets.
Highlights
Fast dissolving tablets are new emerged solid dosage forms over conventional tablets having advantages of both solid and liquid dosage systems
The Fourier-transform infrared spectroscopy (FTIR) spectrum of starch and starch phthalate is shown in fig. 1(A and B)
The presence of peaks of absorption at 1691.57 cm-1 characteristic peaks of ester, so from Fourier-transform infrared spectroscopy (FTIR) studies it was concluded that starch phthalate was formed when starch was allowed to react with phthalic anhydride
Summary
Fast dissolving tablets are new emerged solid dosage forms over conventional tablets having advantages of both solid and liquid dosage systems. It offers convenience in tablet manufacturing, more accurate dosing than the liquid dosage forms [1]. These tablets dissolve fast as it comes in contact with saliva and providing the ease of administration which results in patient’s compliance for pediatrics, geriatrics, dysphasic, psychic, and bed-ridden, unconscious population [2, 3]. Super-disintegrants are the agents which help in rapid disintegration of tablets when they used in low concentration [6]
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