Abstract
Formulation & evaluation of Eclipta alba hydro-gel, the medicinal herbal hydrogel was prepared by using alcoholic extracted leaf powder of Eclipta alba, Carbopol-934, Acacia, Glycerin Sodium benzoate and HPMC. Leaves in concentration (1% and 5%) and evaluated using physiological measurements. The prepared herbal hydrogel formulation was studied for pre-liminary evaluation such as Viscosity, pH, Spreadibility, Rheological studies, Skin irritation test and Drug content uniformity Accelerated stability studies for 3 months. The Formulated hydrogel pH was found to range of 6.45 to 6.68, which lies in the normal pH range of the skin. The formulations did not produce any skin irritation, i.e., erythematic and edema for about a week, when applied over the skin. The viscosity of formulation was range 1024 which spread on the skin properly. On the basis of evaluation study, it can be concluded that Eclipta alba Linn. Medicinal herbal hydrogel may be used for wound healing, antibacterial and antifungal activity anticancer, Anti-inflammatory activity.
Highlights
The nature of Hydro-gels is hydrophilic, three-dimensional and polymeric network of hydrogel capable to absorbing the high amounts of water/biological fluids
Sodium alginate and methyl cellulose gel was opaque in appearance. 2.5.2 pH Assessment of Eclipta alba gel The pH values of Eclipta alba gel was checked via a pH Meter at constant temperature and the PH was 6.4 found in hydrogel formulation. 2.5.3 Spread ability test Spread-ability can be analyzed by applying the hydro-gel over an even surface and observed for the grittiness of Eclipta alba hydrogel. 2.5.4 Viscosity assessment of Eclipta Alba hydrogel Viscosity is an important feature to determine the resistance of flow of gel formulation so that it can spread on the skin properly
It was determined with the help of viscometer (Brookfield) using 2 numbersand the viscosity of hydrogel 1024μ. 2.5.5 Drug content For assay of the hydrogels, eclipta alba was extracted from 1 g formulations with 20 mL of phosphate buffer pH7.4 for 30 min
Summary
The nature of Hydro-gels is hydrophilic, three-dimensional and polymeric network of hydrogel capable to absorbing the high amounts of water/biological fluids. The high water content, soft consistency and porosity, they closely simulate the natural living tissues, as compare to other synthetic bio-materials formulations. Hydro-gels may be stable chemically, disintegrates and dissolved This Hydro-gel may be changed or stable it depends upon the nature of various functional Group presents their structure. The charged Hydro-gels exhibit changes, swelling upon unusual pH and they can go through changes in form & consistency when hydro-gel exposed to electric fields. The chemically Hydro-gels are generally formulated in twodifferent methods: ‘three-dimensional polymerization in this method a monomers of hydrophilic are polymerized in the existence of a multifunctional cross-linking agent, or by hydrogel forms direct linked to water-soluble polymers[1,2]. Synthetic polymers are usually equipped using chemical polymerization methods that forming Hydro-gels[3]
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