Abstract
Gel formulation provides better application property and stability in comparison to cream and ointment. Topical gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. Topical application of drugs offers potential advantages of delivering the drug directly to the site of action and acting for an extended period of time. Topical gels are intended for skin application or to certain mucosal surfaces for local action or percutaneous penetration of medicament or for their emollient or protective action. Gels are evaluated by following parameters such as pH, homogeneity, grittiness drug content, viscosity, spreadability, extrudability, skin irritation studies, in-vitro release, in Stability.
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