Formulation and Evaluation of Niosomal Gel for Treatment of Acne

Abstract

A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. Acne vulgaris is a chronic inflammatory dermatosis which is notable for open and/or closed comedones (blackheads and whiteheads), and inflammatory lesions including papules, pustules, or nodules. It is a disorder of sebaceous follicles which are special pilosebaceous units located on the face, chest, and back. Skin is one of the most readily available organs on human body for topical management and is the major route of topical drug delivery system. Topical drug administration is a localized drug delivery system everywhere in the body during ophthalmic, vaginal, rectal and skin as topical routes. SA niosomes gel delivery system (SANG1 to SANG5) as a dispersed system, which consists of small droplets and well distributed in to immiscible vehicle. Niosome salicylic acid was prepared by Reverse phase evaporation method using cholesterol and span 80 and tween 20. Niosome were evaluated for vesicle shape, size determination, Entrapment efficiency and in-vitro drug release study. The result concluded that SANG5 was best formulation with Carbopol 940 (2g), PVP, nutmeg oil base. The drug release profile and release kinetics are two important characteristics of the dosage forms, which play an important role for describing dissolution profile of dosage form.
 Keywords: Topical drug delivery, Acne vulgaris, Niosomes, Gel, Carbopol 940, nutmeg oil