Abstract
This research work aims to develop glipizide tablets using Hibiscus rosasinensis leaves mucilage. The mucilage was extracted by using double distilled water and precipitated with ethanol. The precipitated mucilage was dried and grounded into powder. The tablet utilizing the mucilage as excipient was prepared by wet granulation method. The tablets were subjected to various tests. The evaluatory parameters of tablets were found to be within the limits as per United States Pharmacopoeia NF 24/19. FTIR spectrum reveals that there is no incompatibility between the ingredients used. Diabetes was induced in wistar albino rats using streptozotocin and effect of formulation on blood glucose level was determined. It was observed that the formulation could not sustain the release of glipizide. However, the glipizide release was retarded as the amount of mucilage was increased. It was observed that on the completion of antidiabetic study, the formulation could bring the blood glucose level to normal in group rats. However, the blood glucose level was still elevated in group administered with pure gliplizide. It can be concluded that HRM can be used to formulate glipizide tablets. The formulations with HRM shows better hypoglycemic activity and this may be attributed to antidiabetic activity of Hibiscus rosasinensis .
Highlights
The therapeutic efficacy and stability of any formulation depends on active pharmaceutical ingredients, and on the excipients used and manufacturing process (Bahadur et al, 2014)
Excipients from natural sources have gained tremendous interest amongst researchers. This may be attributed to number of advantages that excipients from natural sources have over excipients from synthetic or semi synthetic sources
This may be due to the fact that Hibiscus rosasinesis (HR) has antidiabetic activity as reported in many literatures and the mucilage extracted from HR may have acquired the antidiabetic property. This could have potentiated the activity of glipizide and thereby showing better results than the groups treated with glipizide alone. It has been demonstrated in this study that HR mucilage (HRM) can be used as binder for formulation of glipizide tablets
Summary
The therapeutic efficacy and stability of any formulation depends on active pharmaceutical ingredients, and on the excipients used and manufacturing process (Bahadur et al, 2014). Excipients from natural sources have gained tremendous interest amongst researchers. This may be attributed to number of advantages that excipients from natural sources have over excipients from synthetic or semi synthetic sources. Deficiency of insulin secretion or inaction of insulin leads to a group of metabolic diseases, commonly known as diabetes. This leads to chronic hyperglycemia and causes long term damage to different organs (American Diabetes Association, 2014). Oral antidiabetic agents can be administered for management of blood glucose level in type 2 diabetes. Glipizide is extensively and widely used for management of glucose level in type 2 diabetic patients.
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