Abstract
Transferosome, being very flexible and deformable nature to cross stratum corneum are selected for enhancing the transdermal delivery of fusidic acid. The present research work comprised formulation of fusidic acid transferosome using modified reverse phase evaporation process and characterised for particle size, zeta potential, entrapment efficiency and in vitro drug release. An optimised formulation of transferosome made by Phosphatidyl choline S100 and Span 80 (F2) showed lowest size of 145.16 nm and high drug entrapment efficiency of 87.47 ± 0.119. 2 %w/v Carbopol based transferosomal gel formulation (N4) of Fusidic acid showed entrapment efficiency 78.22% and Fickian diffusion-based release mechanism with 47% and 94% drug release at 6 h and 24 h respectively. The promising results from the current study can be exploited in future research for in-vivo performance.
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