Abstract
Gastro-retentive effervescent floating tablets containing quetiapine fumarate (QP) are available using different viscosity grades of HPMC (HPMC K4M, HPMC K15M, and HPMC K100M) and TD made by the direct compression technique.The outcomes of the pre-compression parameters indicate that the powder mix of the formulations of both drugs has shown good micromeritic properties. Every tablet formulation that was made had the same amount of drug in it. The low standard deviation results imply that the drugs are distributed uniformly throughout the matrices.Drug compatibility with excipients is demonstrated by DSC and FTIR testing. It was discovered that the floating lag time was influenced by the concentration of citric acid and sodium bicarbonate. All the formulations (QP1 to QP17) floated for more than 24 hours, while the QP formulations remained buoyant for more than 12 hours. Accordingly, the present study’s results suggest that the QP floating system has a promising future as a substitute for the corresponding conventional dosage form.
Published Version
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