Formulation and Evaluation of Floating and Mucoadhesive Tablets containing Repaglinide

Abstract

In the present study, Repaglinide an anti-diabetic drug is formulated in the form of floating mucoadhesive tablets to improve its bioavailability. Hydroxy Propyl Methyl Cellulose K200M, Sodium Carboxy Methyl Cellulose, Carbopol 974P, Karaya gum, Chitosan, Xanthan gum were used as rate controlling and mucoadhesive polymers in designing the tablets. Various formulations were prepared by using different concentration of polymers. The pre-compression blend of Repaglinide mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr's index and hausner's ratio and all the results indicated that the blend had good flow property and better compressibility. The swelling studies were performed and the results indicated that all the formulations had good swelling index. The results of floating lag time and buoyancy studies suggested that formulations had good floating ability. The drug release studies indicated a controlled and enhanced drug release for a period of 12hrs. In-vivo study was carried out using the optimized formulation. Based on the in-vitro drug release and other related evaluation tests, formulation RT11 containing drug: karaya gum in the ratio 1: 2 was optimized. The drug release of the formulation RT11 followed Higuchi model with regression value of 0.984.