Abstract
Mucoadhesive buccal patches for the delivery of fexofenadine using various polyvinyl alcohol, hydroxypropyl methyl cellulose K4M and K15M and Eudragit L100 were developed using solvent casting technique. The fabricated formulations were evaluated for different physicochemical as well as mechanical parameters such as thickness, surface pH, weight uniformity, swelling index, folding endurance, drug content, percentage moisture loss, in vitro dispersion and in vitro residence time. An in vitro drug release study was designed and performed using freshly prepared egg membrane as semi-permeable membrane. The optimized formulation (F1) showed maximum percentage of drug release 96.18% ± 0.53% by the end of 8 h. The sustained release of the drug was achieved up to 8 h.
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