Abstract
Valdecoxib is a selective COX- II inhibitor with anti – inflammatory, analgesic and antipyretic properties. The poor aqueous solubility of the drug leads to variable dissolution rates. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate. The fast dissolving tablets of Valdecoxib was prepared with some carriers (polymers) and super disintegrants such as Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone NF and β – Cyclodextrin. The above mentioned all carriers and superdisintegrants were taken in different proportions of 5, 10, and 15%. All the formulations of the fast dissolving tablets of Valdecoxib were prepared by direct compression technique. The blend was examined for Angle of repose, Bulk density, Compressibility index and Hausner’s ratio. The prepared tablets were evaluated for hardness, drug content uniformity, friability, disintegration time and dissolution rate. An effective pleasant testing formulation released 99.88% drug within 10 minutes. The prepared formulations drug release was found to be comparable with the marketed dispersible tablets.
 Keywords: Fast dissolving tablets, Super-disintegrants, Valdecoxib, Crosspovidone, Sodium Carboxy Methyl Cellulose.
Highlights
A fast dissolving system can be defined as a solid dosage form for oral administration, which when placed in mouth, rapidly dispersed or dissolved and can be swallowed in the form of liquid
Fast disintegrating tablets which are generally contains several excipients are involved in complex series of dissolution process that begin when the solvent contacts the solid and penetrates the tablet matrix[3]
Oral administration of Valdecoxib is useful in the treatment of variety of painful inflammatory condition, including those associated with osteoarthritis, rheumatoid arthritis, moderate to severe primary dysmenorrheal, sports injuries can be well treated with Valdecoxib
Summary
A fast dissolving system can be defined as a solid dosage form for oral administration, which when placed in mouth, rapidly dispersed or dissolved and can be swallowed in the form of liquid. When the fast disintegrating tablet is orally applied, the drug substance has to be dissolved so that can be absorbed. Valdecoxib is chemically 4(5- methyl- 3- phenyl – 4 – isoxazolyl) benzene sulfonamide and is a diaryl substituted isoxazole derivative. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate
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