FORMULATION AND EVALUATION OF ORODISPERSIBLE ATENOLOL MALEATE TABLETS: A COMPARATIVE STUDY ON NATURAL SUPER DISINTEGRENTS AND SYNTHETIC SUPER DISINTEGRENTS

Abstract

O ral Disintegrating T ablets (ODT s ) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first - pass hepatic metabolism and po tentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The o bjectives of the research work wa s to formulate oral disintegrating tablets of Atenolol maleate by using different super disintegrates (Natural, Synthetic) in di fferent ratio by direct compression technique and tablets were evaluated for pre compression and post compression parameters such as angle of repose, bulk density, tapped density, compressibility index, drug content and in - vitro drug release study, hardnes s, friability, wett ing time and in vitro dispersion time. Among the all formulations , the promising formula (CCS3, IH2) have showed fast disintegration and displayed in vitro d ispersion time of 11 s and 10.5 s. The dissolution rates of the optimized formul ations (CCS3, IH2) were found to be good. Among the promising ODT formulation CCS3, IH2 the formula IH2 was found to be superior when compared to formulation CCS3 since formulation IH2 us ed natural disintegrant (i.e . 6 %w/w Isphagula husk) at a lower conce ntration than the formulation CCS3 (8 % w/w Cross Carmellose Sodium) hence it wa s found to be more cost effective. The FTIR studies also showed that there was no interaction between drug and polymer. Formulation CCS3, IH2 were subjected to stability studie s as per ICH guidelines at temperatures and humidity of 25 ± 5oC/60 ± 5 % RH; and 40 ± 5oC/75 ± 5 % RH. Tablets didn’t reveal any appreciable changes with respect t o hardness, disintegration time , drug content and dissolution profile.