Abstract
Objective: The present study aims to formulate and evaluate Fast dissolving tablet of Buspirone, the drug that is used for management of anxiety, by direct compression method using various Super disintegrants.
 Methods: Ten formulations (F1-F10) of fast dissolving tablets of Buspirone were prepared by using various Superdisintegrants. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption, wetting time, and disintegration time and in vitro dissolution study.
 Results: Among all the formulations, F10 (containing 5 mg of Coprocessed (CS: SSG 1:2) Superdisintegrants) was considered to be the best formulation, which released up to 98% drug in 20 min as compared to a marketed conventional dosage form which dissolves in approx 60 min. The results of stability study of formulation F10 after a period of two months indicated that the formulation was stable.
 Conclusion: It was concluded that a fast-dissolving tablet of Buspirone containing various Superdisintegrants is better and effective to meet patient compliance.
Highlights
The tablet is the most widely used dosage form existing today because of its convenience in terms of self-administration, compactness, and ease in manufacturing
Geriatric, pediatric and mentally ill patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance [1]
Scientists have developed innovative drug delivery system known as mouth dissolving/disintegrating tablets (ODTs) or fast-dissolving tablets [2]
Summary
The tablet is the most widely used dosage form existing today because of its convenience in terms of self-administration, compactness, and ease in manufacturing. Geriatric, pediatric and mentally ill patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance [1]. To overcome these problems, scientists have developed innovative drug delivery system known as mouth dissolving/disintegrating tablets (ODTs) or fast-dissolving tablets [2]. Many techniques are provided to formulate ODT like direct compression, tablet moulding, spray drying, cotton candy process, mass extrusion and freeze-drying [4] Of all these above-mentioned techniques, direct compression technique is most convenient and economical as it does not require any special manufacturing process [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
