Abstract
Fast dissolving tablets (FDT) of Granisetron hydrochloride were prepared by direct compression method after incorporating superdisintegrants croscarmellose sodium and crospovidone in different concentrations (2.5, 5, 7.5 and 10 mg). Eight formulations having superdisintegrants at different concentration level were prepared to assess their efficiency and critical concentration level. Different type of evaluation parameters for blends and tablets were used. The prepared tablets were characterized by FTIR studies. No chemical interaction between drug and exciepients was confirmed by FTIR studies. The formulation GCS 4 containing croscarmellose sodium showed superior in vitro , in vitro dispersion time and drug release, as compared to other formulations. GCS 4 tablet showed good dissolution efficiency and rapid dissolution. The 50% and 90% of drug release of tablet GCS 4, was found within 0.45 and 2.59 min.
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