Abstract

Now days tablet dosage forms are supplanted by new drug delivery system because of problems like hepatic metabolism, GI toxicity and enzymatic degradation which leads to non-compliance and ineffective therapy. These problems can be overcome by formulating the drug into fast dissolving buccal patches for oromucosal absorption with fast onset of action and improved bioavailability. In present work the fast dissolving buccal patches of Olmesartan medoxomil was prepared by solvent casting method using HPMC E5, HPMC 3cps and HPMC K100 as a film formers and PEG 400 as plasticizer. The prepared patches were evaluated for weight, thickness, folding endurance, surface pH, disintegration time, in-vitro drug release and stability studies on optimized formulation. The thickness of the all patches was found in the range of 0.22 to 0.30 mm. The disintegration time was found up to 60 sec. and the folding endurance was up to 200. The in-vitro drug release was found to be up to 100% within 2 minutes. Thus the fast dissolving buccal patch of Olmesartan medoxomil was successfully formulated to achieve a safe, rapid and effective dosage form with enhanced drug dissolution and rapid antihypertensive therapy.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.