Abstract
Objective: The aim of present work was to formulate and evaluate Dasatinib (DST) loaded solid lipid nanoparticles (SLNs) as a potential anticancer drug delivery system by enhancing its solubility.Methods: SLNs consist of a solid lipid matrix where the drug was incorporated. Surfactants of GRAS grade were used to avoid aggregation and to stabilize the SLNs. DST-SLNs formulations of varying concentrations were prepared by high speed homogenization technique and evaluated for drug excipients compatibility study, poly-dispersity index, particle size analysis, surface morphology, zeta potential and drug release features.Results: It was observed that DST-SLNs with optimum quantities of poloxomer: lecithin ratio showed 88.06% drug release in 6h with good entrapment efficiency of 76.9±0.84 %. Particle size, Poly dispersity index, zeta potential and drug entrapment efficiency for the optimized formulation was found to be optimum. Stability studies revealed that the entrapment efficiency of the SLN dispersion stored in 4 °C was stable.Conclusion: Thus, it can be concluded that formulations of DST loaded SLNs are suitable carriers for improving the solubility and dissolution related problems.
Highlights
A large number of new drug molecules with varied therapeutic potentials have been discovered in the recent decade, yet most of them are still in the developmental process
The results indicate that both poloxamer and lecithin played a pivotal role in the encapsulation efficiency of the drug
SLNs have emerged as a promising drug delivery system in recent years as its potential is gradually and eventually being realized
Summary
A large number of new drug molecules with varied therapeutic potentials have been discovered in the recent decade, yet most of them are still in the developmental process. This can be attributed to the limited aqueous solubility which governs the bioavailability of such drug molecules. Many different approaches have been developed to overcome the solubility problem of poorly soluble drugs including solubilization, inclusion compounds and complexation. An alternative to these methods developed was drugnanoparticle formulation
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