Abstract
The aim of present study is to formulate and characterize darifenacin hydrobromide transdermal patch and the effects of non-ionic surfactants span 20 and tween 20 on drug permeation were studied. Transdermal patches were prepared by solvent casting method using PVA, PVP, HPMC E5, HPMC E15 polymers. Propylene glycol and Glycerol were used as plasticizers and Span 20 and Tween 20 were used as permeation enhancers. The prepared patches were evaluated for physicochemical properties like drug content, thickness, weight variation, folding endurance, moisture uptake, watervapour transmission studies. Physicochemical properties have shown better. Drug release studies by in-vitro diffusion, ex-vivo permeation as well as skin irritation. Formulations DPAT2, DPLT3 showed better drug release rate, ux and Q when compared to DPAS2, DPLS2. From the results it was concluded that darifenacin hydrobromide transdermal patch 24 (DPAT2) formulation would reduce the administration frequency, side effects and may avoid uctuations of drug level in the blood in comparison to immediate release formulations which might enhance the patient compliance.
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