Abstract
Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers. Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study. Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release. Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance.
Highlights
Administration of dosage forms through the oral route is the most convenient and suitable route
Eclipta prostrate known as bhringraj, is a famous herb widely used for hair growth, productive cough, ulcers, asthma and liver disorders
In the present investigation leaf extract of Eclipta prostrate was formulated into fast dissolving films to treat mouth ulcers [26]
Summary
Administration of dosage forms through the oral route is the most convenient and suitable route. Some classes of patients are facing difficulty to take oral formulations i.e. geriatric, pediatric and dysphagia patients due to difficulty of swallowing or chewing dosage forms [1, 2]. Fast dissolving films having the ability to dissolve and disintegrate quickly in a few seconds when placed on a patient's tongue or in oral mucosa and release the drug for oromucosal or intragastric absorption. They offer a number of advantages over other solid dosage forms viz., tablets and capsules by eliminating swallowing problems and maintaining water, which leads to more patient compliance. The design of oral films with herbal extract is an interesting trend
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